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Management of atopic dermatitis The next challenge for probiotics

NICOLE B. M. M. RUTTEN1*, ISOLDE BESSELING-VAN DER VAART2, ARINE M. VLIEGER1, GER T. RIJKERS3*
*Corresponding authors
1. St. Antonius Hospital, Department of Pediatrics, P.O. Box 25003430 EM, Nieuwegein, The Netherlands
2. Winclove Bio Industries BV, Hulstweg 11, 1032 LB, Amsterdam, The Netherlands
3. St. Antonius Hospital, Department of Medical Microbiology and Immunology P.O. Box 2500, 3430 EM, Nieuwegein, The Netherlands

Abstract

An accumulating amount of evidence points towards an intimate interplay between the mucosal immune systemand the gut microbiota, with allergy as a clear example. Because of this relationship, probiotics have a high potential and havealready been shown to have promising effects in immune-modulation. Nevertheless, the literature clearly suggests that probioticsexhibit strain-specific properties which may explain the sometimes conflicting outcomes. The approach of carefully selectingprobiotic strains for a specific application has proven to be successful in prevention of atopic dermatitis (eczema). Therefore, thefirst step in designing the next generation multispecies probiotic formulation for the management of existing eczema has beenmade by using the same integrative approach. This newly developed multispecies probiotic product will be studied in vivo for itseffectiveness in the management of eczema.


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