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P. 28-33 /

Peptide rope tricks

K. JOHAN ROSENGREN, DAVID J. CRAIK*
*Corresponding author
The University of Queensland, Institute for Molecular Bioscience, Brisbane, QLD 4072, Australia

Abstract

Lariat or lasso peptides are a structurally uniquefamily of ribosomally synthesized bioactive peptides producedby microbes. They range from 16 to 21 residues in size andare characterized by a post-translational modification inthe form of a lactam bond between a conserved asparticor glutamic acid and the peptide N-terminus, resulting inan 8 or 9 residue macrocycle, which is threaded by theC-terminal part of the peptide chain. This noose-like featureresults in unique properties, including remarkable chemicaland biological stability, suggesting that this bacterial ropetrick may well provide an ideal new framework for the designof peptide based pharmaceuticals.


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