Polyphenols as Xenohormetics
The future approach to prevent human chronic diseases
*Member of AgroFOOD industry hi-tech’s scientific advisory board
Universidad Miguel Hernández, Instituto de Biologia molecular y celular Avda. de la Universidad s/n., Elche (Alicante), E-03202, Spain
Current remedies or pharmaceutical drugs for major human diseases such as obesity, diabetes, cancer, and cardiovascular diseases, are devoid of efficacy. Obesity and its related metabolic diseases are increasing on Western society. Over two-thirds of adults in the United States are either overweight or obese, and over one-third of them are obese, according to data from the National Health and Nutrition Examination Survey (NHANES) 2003-2006 and 2007-2008. The search for new natural therapies is an interesting research field that can improve the results of existing treatments. One-third of the current top twenty drugs on the market are plant derived and often, new plant molecules are emerging to have some application in human health (1). On the contrary, only one out of 5,000-10,000 of the new synthetic molecules in development becomes a commercial pharmaceutical drug. There is also a concern about the influence of the pharmaceutical industry on the scientific process for the development of new drugs. Meta-analyses have shown that studies sponsored by pharmaceutical companies are several times more likely to report positive results. All these factors are promoting numerous scientific ...