Sustainable synthesis of secondary amines
Direct reductive amination or hydrogen borrowing over heterogeneous Cu catalysts
The development of more sustainable, efficient, and selective procedures to access high added value organic compounds is one of the fundamental research goals in modern chemistry. This goal can be achieved by increasing the selectivity, and hence yield, of the reactions and by reducing the lead time of the entire production process through the introduction of multifunctional processes (1). In this context the synthesis of amines, that are key moieties in both pharmaceutically active molecules and natural products (2), by means of one step-one pot processes would be a very attractive approach (3). Moreover, to find a simple and reliable heterogeneous system, able to substitute the N-alkylation of amines with toxic alkyl-halides, would strongly improve the environmental impact of this process. In the present work we would like to report the results of our studies about direct reductive amination of ketones (4) and amination of alcohols by borrowing hydrogen (5) with the use of different heterogeneous copper catalysts.
RESULTS AND DISCUSSION
Direct reductive ... ...