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The secret to regenerate the matrix network
Periostin, a novel anti-ageing arm

corresponding

Pauline Rouaud-Tinguely*, Florence Lalande, Katia Servaes, Aurélien Tinguely, Brigitte Closs
*Corresponding author
SILAB, BP 213, 19108, Brive cedex, France

Abstract

Periostin was first identified in the area of bone regeneration. It is a matricellular protein, the subject of a large body of basic research because it is involved in the tissue remodelling of several organs. Many studies on the skin have shown its key role in the cross-linking of collagen fibrils required for matrix network organisation. The expression of periostin decreases in the course of ageing and so, it is essential to restore its synthesis in the framework of skin regeneration.
SILAB has developed a natural active ingredient that can compensate the loss of periostin occurring in the course of ageing.
The architecture of the dermal matrix is restored in vivo, skin elasticity is increased and facial contours are restructured.


INTRODUCTION

The notion of tissue regeneration appeared in 1980. The results of regenerative medicine revealed the restructuring effects of the extracellular matrix (ECM). Stephen Badylak used an excised piece of dog intestine to repair defects of a coronary artery. Six months later, it was shown that the intestinal graft had disappeared, replaced by a tissue with the characteristics of an artery (1). More detailed investigations showed that the ECM, previously considered as a simple scaffolding, in reality has powerful regenerating properties (2, 3).

After transposing these finding to humans, additional studies were conducted, in particular on the skin. The ECM is the genuine architectural cornerstone of the dermis. It is composed of glycoproteins, fibres, growth factors and proteoglycans synthesised and secreted locally by dermal cells: fibroblasts (4). Research on this skin compartment has focused on a family of extracellular proteins named matricellular proteins. These are a group of disparate proteins including the galectins, osteopontin, SPARC, tenascins, thrombospondins, vitronectin and perhaps others. While matricellular proteins are devo ...




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