Biotechnological approach to mitigate skin exposome – A specific guardian for microbiota care


*Corresponding author
ROELMI HPC Srl, Origgio, Varese, Italy


Skin is the perfect ecosystem in which billions of microorganisms live and continuously interact with skin cells providing a safe environment capable of maintaining biodiversity. However, chronic exposure to UV rays, pollution and other substances negatively affects our skin microbiota. Preserving the diversity of skin microorganisms plays an important role in defending the organism against the activation of immune phenomena that trigger inflammation. The alteration of skin microbiota, known as dysbiosis, has been associated to exposome-induced damages manifesting as skin disorders and, it concurs to weak skin barrier integrity and consequent sensitivity.

This work aims at presenting the evidence of effectiveness towards a biotechnological-based dermobiotic approach for the prevention versus skin exposome undesired distresses and for the rebalance of skin environment.


Skin microbiota represents all the microorganisms living on the upper layers of the skin, the interaction between commensal microorganisms and skin cells is responsible of balanced biodiversity, an essential condition called eubiosis.

When life begins, skin microbiota starts to form and balance in terms of composition and like a fingerprint represents a unique feature of every single person chaperoning throughout the entire life cycle (1).


Microorganisms are essential to maintain skin homeostasis; for that reason skin microbiota is involved in defense against pathogens, external stresses that can occur by altering the skin ecosystem; these alterations are shown as a changing in microorganism number and also in taxonomical composition (2).


When environmental stresses occur, the skin ecosystem equilibrium is lost and natural immune defenses are activated to counteract the inflammation occurring (3). Several ingredients have been developed aiming at serving the microbiota care. An ingredient targeting the rebalance of skin ecosystem is represented by the subject of this study: ectoin. In fac ...