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P. 22-25 /

Critical parameters for solid-phase manufacturing of therapeutic peptides

THOMAS VORHERR
Bachem Holding AG
Hauptstr. 144
Bubendorf, 4416, Switzerland

Abstract

Solid-phase peptide synthesis(SPPS) represents the standardfor cGMP-peptide manufacturing. Recent improvements inchemistry & technology are highlighted. In the field ofchemistry, scope and limitations for the application ofinnovative building blocks, e.g., pseudo-proline dipeptides,and the new coupling reagent COMU are summarized. Onthe technology side, the inverted filter centrifuge as adevice to support large-scale final cleavage of the peptidefrom the resin is described. Both, additional innovativeengineering solutions and progress in chemistry are thoughtto further increase productivity for the manufacturing oftherapeutic peptides following a solid-phase process.


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