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Fast optimisation of a Diels-Alder reaction in a flow microreactor by in-line HPLC analysis

*Corresponding author
Cardiff University, School of Chemistry, Park Place, Cardiff CF10 3AT, Wales, United Kingdom


A continuous-flow microreactor is used for Diels-Alderreactions. Its direct in-line connection to an HPLC allowsthe analysis and optimisation of the reaction on a muchshorter time scale than performing the correspondingreactions under batch reaction conditions. A large numberof experiments are performed in a short time with minimalreagent consumption. Together with very small volumes ofsolvents, such an approach provides a green, economicaland safe environment for reaction screening.