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First Cannabis sativa stem cells: Nourishing the skin microbiota


*Corresponding author
Vytrus Biotech S.L., Terrassa, Barcelona, Spain


The skin and the brain are connected through an existing natural pathway where the microbiota may play an important role. The new active Kannabia SensePLF (INCI name: Cannabis Sativa Callus Lysate), is the first generation of Cannabis sativa plant stem cells and introduces the concept of in-situ postbiotic. Through its mechanism of action, the active modulates the skin commensal microbiota to produce an in-situ postbiotic cocktail that ignites the synthesis of positive neurochemicals from the skin that connects with the brain through the cascade of cell-to-cell communication from the microbiota to the keratinocytes to the cutaneous sensory neurons, turning into a well-being response and a healthier and stronger skin. Several in vitro and in vivo trials were performed to demonstrate the skin well-ageing effect, positive brain activation and modulation of mood state thanks to the active.


The skin is a mirror of your emotional state and internal conflicts because it is linked to the nervous system since its embryonic development (1).


The latest literature describes the skin as the third brain or as the new neuroendocrine organ. It has been demonstrated that cutaneous cells are able to synthesize a plethora of endocrine neurochemicals like dopamine, oxytocin, endorphins, histamine, serotonin, adrenaline (2-7).  


The digestive system has been described as playing a role similar to the brain regards to reception and transmission of information, being considered as ‘the second brain’. 

The skin, which forms the interface between the body and the environment, could be considered our ‘third brain’. 

The human keratinocytes can generate endocrine neurochemicals, so the epidermis plays a significant role in adapting body physiology and emotional response to changing environments. The skin is also a social organ since ...

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