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Microwave heating in solid-phase peptide synthesis Rise of the robots

A. PERNILLE TOFTENG*, LEILA MALIK, SØREN L. PEDERSEN, KASPER K. SØRENSEN, KNUD J. JENSEN*
*Corresponding authors
Copenhagen University, Faculty of Life Sciences, Section of NanoBioScience, DK-1871, Denmark

Abstract

Fast and precise heating by microwave irradiation has emergedas a valuable tool in the solid-phase synthesis of difficult peptidesequences and protein domains. This paper describes the stepsthat led to the development of a new synthesis robot for microwaveassisted solid-phase peptide synthesis. The paper concludes withsome examples of the use of the instrument for the synthesis of difficultpeptide sequences.


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