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The role of L-arginine in human pregnancy

MARISOL CASTILLO-CASTREJON, ALEJANDRA MIGOYA-GRAUE, NOEMÍ MERAZ-CRUZ, FELIPE VADILLO-ORTEGA*
*Corresponding author
Universidad Nacional Autonoma de Mexico, Department of Biochemistry, School of Medicine,Ciudad Universitaria 3000, Torre de Investigación 3er piso, Mexico City, 04510, Mexico

Abstract

L-arginine is a semi-essential amino acid dependent upon the functional circumstances. Pregnancy is a condition
in which demands for L-arginine are increased because of the foetal and placental growth, increased catabolism in women
and increased production of nitric oxide for vasculature function. L-arginine defi cient-diets have been linked to poor pregnancy outcomes including foetal loss, intrauterine growth restriction, and pre-eclampsia. Strong evidence that supplementation
with L-arginine during pregnancy results in signifi cative reduction of new cases of pre-eclampsia is available. This makes supplementation of this amino acid a cost-effective intervention during human pregnancy. Further research is needed to test its
use in general population of pregnant women.


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