Recent evolutionof flow-modulation comprehensive gas chromatographywithin the context of mass spectrometry hyphenation
KEYWORDS: Comprehensive two-dimensional gas chromatography, flow modulation, mass spectrometry, method optimization.
ABSTRACT: The present short review (based on research performed by the authors reported above) describes recent evolution (2011-2016 period) of flow modulation (FM) comprehensive two-dimensional gas chromatography (GC×GC), within the context of mass spectrometry (MS) hyphenation. Specifically, it will be shown how intensive research on an FM model has enabled a great reduction in gas flows (down to approx. 4 mL min-1), making the combination of GC×GC and MS now much easier.
Comprehensive two-dimensional gas chromatography (GC×GC) is now a well-established multidimensional GC method, it being introduced nearly 25 years ago (1). In GC×GC, a device named modulator enables the continuous and sequential transfer of “heart-cuts” from a primary to a secondary column. Separations in the second dimension (2D) are usually very rapid, normally less than 10 s. GC×GC data are visualized in a two-dimension (2D) format, ...